Pathophysiology

The persistence of hydronephrosis can lead to:

  • Tubular atrophy
  • Inflammation
  • Fibrosis

Visualizing the physiological process:

1

- Elevated hydrostatic pressure with obstruction

2

- Increased epithelial apoptosis/tubular atrophy - Infiltration of immune cells - Induction of numerous cytokines - Fibrosis

3

- Reduction in GFR
Obstructive uropathies | 1. Basics of obstructive uropathy
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